B Cell Receptor Signaling (current Topics In Microbiology And Immunology)
by Tomohiro Kurosaki /
2015 / English / EPUB
1.7 MB Download
This volume details our current understanding of the architecture
and signaling capabilities of the B cell antigen receptor (BCR)
in health and disease. The first chapters review new insights
into the assembly of BCR components and their organization on the
cell surface. Subsequent contributions focus on the molecular
interactions that connect the BCR with major intracellular
signaling pathways such as Ca
This volume details our current understanding of the architecture
and signaling capabilities of the B cell antigen receptor (BCR)
in health and disease. The first chapters review new insights
into the assembly of BCR components and their organization on the
cell surface. Subsequent contributions focus on the molecular
interactions that connect the BCR with major intracellular
signaling pathways such as Ca2+
2+ mobilization, membrane
phospholipid metabolism, nuclear translocation of NF-kB or the
activation of Bruton’s Tyrosine Kinase and MAP kinases. These
elements orchestrate cytoplasmic and nuclear responses as well as
cytoskeleton dynamics for antigen internalization. Furthermore, a
key mechanism of how B cells remember their cognate antigen is
discussed in detail. Altogether, the discoveries presented
provide a better understanding of B cell biology and help to
explain some B cell-mediated pathogenicities, like autoimmune
phenomena or the formation of B cell tumors, while also paving
the way for eventually combating these diseases.
mobilization, membrane
phospholipid metabolism, nuclear translocation of NF-kB or the
activation of Bruton’s Tyrosine Kinase and MAP kinases. These
elements orchestrate cytoplasmic and nuclear responses as well as
cytoskeleton dynamics for antigen internalization. Furthermore, a
key mechanism of how B cells remember their cognate antigen is
discussed in detail. Altogether, the discoveries presented
provide a better understanding of B cell biology and help to
explain some B cell-mediated pathogenicities, like autoimmune
phenomena or the formation of B cell tumors, while also paving
the way for eventually combating these diseases.