Carcinogenesis Ed. By Kathryn Tonissen

Carcinogenesis Ed. By Kathryn Tonissen
by Kathryn Tonissen / / / PDF

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This book commences with chapters discussing cancer predisposition and pre-cancerous lesions. Factors that initiate or progress cancer development, including viral, hormonal, oncogenic and biochemical stimuli are then described, as are interactions with the cancer extracellular environment. Carcinogenesis covers molecular, biochemical and cellular processes that underpin this field. The complex nature of cancer means that a broad understanding of these processes is advantageous when designing novel preventative, therapeutic or diagnostic strategies. Animal models are particularly useful for evaluating therapeutic or chemopreventive agents and examples are presented. Finally, natural products that ether prevent or treat cancer are described. Together these topics will provide the reader with examples of the latest cutting edge research and discoveries, with the goal of stimulating further advances. Preface Section 1 Cancer Pre-Disposition and Pre-Cancerous Risk Classification 1 Synergistic Effects of Low-Risk Variant Alleles in Cancer Predisposition 2 Binary System of Grading Epithelial Dysplasia in Oral Leukoplakias Section 2 Cancer Development and Progression 3 Human Papillomavirus and Carcinogenesis in the Upper Aero-Digestive Tract 4 Oestrogens, Xenoestrogens and Hormone-Dependent Cancers 5 EPS8, an Adaptor Protein Acts as an Oncoprotein in Human Cancer 6 FJ194940.1 Gene and Its Protein Product ACJ04040.1 - Potential Tumor Marker - From Protein to cDNA and Chromosomal Localization 7 The Interaction Between Redox and Hypoxic Signalling Pathways in the Dynamic Oxygen Environment of Cancer Cells 8 ExpressionaI Alterations of Versican, Hyaluronan and Microfibril Associated Proteins in the Cancer Microenvironment 9 Molecular Mechanisms of Metastasis: Epithelial-Mesenchymal Transition, Anoikis and Loss of Adhesion Section 3 Animal Model Systems to Study Carcinogenesis 10 Lobe-Specific Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Mouse Model 11 Mechanism of Urinary Bladder Carcinogenesis Induced by a Xanthine Oxidoreductase Inhibitor, in Rats Section 4 Natural Products that Prevent or Treat Cancer 12 Cancer Chemoprevention by Dietary Polyphenols 13 Kuguacin J, a Triterpenoid from Momordica charantia Linn: A Comprehensive Review of Anticarcinogen ic Properties 14 Regulation of Apoptosis, Invasion and Angiogenesis of Tumor Cells by Caffe ic Acid Phenethyl Ester

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