Mitochondrial Signaling In Health And Disease (oxidative Stress And Disease)
by Lester Packer /
2012 / English / PDF
5.4 MB Download
Mitochondria have traditionally been associated with metabolic
functions; however recent research has uncovered a central role
for these organelles in cell signaling, cell survival, and cell
death. Mitochondrial dysfunction is a factor in a myriad of
pathophysiological conditions, including age-related
neurodegenerative disorders, cancer, metabolic syndrome, and
cardiovascular disease.
Mitochondria have traditionally been associated with metabolic
functions; however recent research has uncovered a central role
for these organelles in cell signaling, cell survival, and cell
death. Mitochondrial dysfunction is a factor in a myriad of
pathophysiological conditions, including age-related
neurodegenerative disorders, cancer, metabolic syndrome, and
cardiovascular disease.Mitochondrial Signaling in Health
and Disease
Mitochondrial Signaling in Health
and Disease examines themes essential for the
maintenance of the mitochondrial redox (reduction-oxidation)
energy axis.
examines themes essential for the
maintenance of the mitochondrial redox (reduction-oxidation)
energy axis.
With contributions from an impressive cadre of internationally
recognized scientists, the book discusses coordinated
mitochondrial functions that regulate cell function by discrete
signaling pathways. Topics discussed include:
With contributions from an impressive cadre of internationally
recognized scientists, the book discusses coordinated
mitochondrial functions that regulate cell function by discrete
signaling pathways. Topics discussed include:Electron transport and energy production
Electron transport and energy productionMitochondrial biogenesis and dynamics
Mitochondrial biogenesis and dynamicsMitochondrial signaling
Mitochondrial signalingApoptosis and autophagy
Apoptosis and autophagyPharmacology signaling
Pharmacology signalingEpigenetic signaling: mitochondrial methylation and
acetylation reactions
Epigenetic signaling: mitochondrial methylation and
acetylation reactions
An essential resource for life and health scientists as well as
pharmaceutical industry professionals, this volume highlights the
importance of mitochondrial signaling and its role in
establishing a harmonized communication between several cellular
compartments. The information in this volume is critical to those
developing mitochondrion-targeted therapies aimed at assuaging
mitochondrial dysfunction or the specific factors contributing to
its dysfunction.
An essential resource for life and health scientists as well as
pharmaceutical industry professionals, this volume highlights the
importance of mitochondrial signaling and its role in
establishing a harmonized communication between several cellular
compartments. The information in this volume is critical to those
developing mitochondrion-targeted therapies aimed at assuaging
mitochondrial dysfunction or the specific factors contributing to
its dysfunction.
