Sex And Gender Factors Affecting Metabolic Homeostasis, Diabetes And Obesity (advances In Experimental Medicine And Biology)
by Franck Mauvais-Jarvis /
2017 / English / PDF
16.3 MB Download
The book provides a reference for years to come, written by
world-renowned expert investigators studying sex differences,
the role of sex hormones, the systems biology of sex, and
the genetic contribution of sex chromosomes to metabolic
homeostasis and diseases. In this volume, leaders of the
pharmaceutical industry present their views on sex-specific
drug discovery. Many of the authors presented at the Keystone
Symposium on “Sex and gender factors affecting metabolic
homeostasis, diabetes and obesity” to be held in March 2017
in Lake Tahoe, CA. This book will generate new knowledge and
ideas on the importance of gender biology and medicine from a
molecular standpoint to the population level and to provide
the methods to study them. It is intended to be a catalyst
leading to gender-specific treatments of metabolic diseases.
The book provides a reference for years to come, written by
world-renowned expert investigators studying sex differences,
the role of sex hormones, the systems biology of sex, and
the genetic contribution of sex chromosomes to metabolic
homeostasis and diseases. In this volume, leaders of the
pharmaceutical industry present their views on sex-specific
drug discovery. Many of the authors presented at the Keystone
Symposium on “Sex and gender factors affecting metabolic
homeostasis, diabetes and obesity” to be held in March 2017
in Lake Tahoe, CA. This book will generate new knowledge and
ideas on the importance of gender biology and medicine from a
molecular standpoint to the population level and to provide
the methods to study them. It is intended to be a catalyst
leading to gender-specific treatments of metabolic diseases.
There are fundamental aspects of metabolic homeostasis that are
regulated differently in males
There are fundamental aspects of metabolic homeostasis that are
regulated differently in malesand females, and influence both the development of
diabetes and obesity and the response to pharmacological
intervention. Still, most preclinical researchers avoid studying
female rodents due to the added complexity of research plans.
The consequence is a generation of data that risks being
relevant to only half of the population. This is a timely
moment to publish a book on sex differences in diseases as NIH
leadership has asked scientists to consider sex as a biological
variable in preclinical research, to ensure that women get the
same benefit of medical research as men.
and females, and influence both the development of
diabetes and obesity and the response to pharmacological
intervention. Still, most preclinical researchers avoid studying
female rodents due to the added complexity of research plans.
The consequence is a generation of data that risks being
relevant to only half of the population. This is a timely
moment to publish a book on sex differences in diseases as NIH
leadership has asked scientists to consider sex as a biological
variable in preclinical research, to ensure that women get the
same benefit of medical research as men.
