Advances In Veterinary Dermatology, Volume 8
2017 / English / PDF
8.3 MB Download
Edited By Sheila M.F. Torres
Proceedings of the Eighth World Congress of Veterinary Dermatology
Bordeaux, France
31 May – 4 June 2016
From The Book:
Tight junctions
Humans
Tight junction proteins, such as claudins and occludins, regulate the attachment of keratinocytes and the transition
of molecules by forming the second physical barrier. In humans with AD, expression of claudin-1 was shown
to be reduced and inversely correlated with Th2 biomarkers. 21 Furthermore, identification of claudin-1 SNPs
revealed its association with AD in North American populations. 21 These results suggest that impairments in tight
junctions due to a reduction of claudin-1 contribute to dysfunction of the second physical barrier in humans with
AD.
