Alternatives For Dermal Toxicity Testing
by Howard I. Maibach /
2017 / English / PDF
7.7 MB Download
This book provides comprehensive information on the alternative
(non-animal) dermal toxicity test methods currently available for
industrial, regulatory, and academic use and also explores
potential future developments. It encompasses all areas of dermal
toxicity, including skin irritation, skin corrosion, skin
sensitization, UV-induced effects, and skin genotoxicity. An
individual chapter is devoted to each test method, with coverage of
the scientific basis, validation status and regulatory acceptance,
applications and limitations, available protocols, and potential
role within testing strategies. In addition, perspectives from the
test developer are presented, for example regarding critical steps
in the protocol. The closing section addresses areas that may be of
relevance for the future of dermal toxicity safety testing,
including the validation and regulatory acceptance of integrated
testing strategies, novel complex skin models, and high-throughput
screening techniques.
This book provides comprehensive information on the alternative
(non-animal) dermal toxicity test methods currently available for
industrial, regulatory, and academic use and also explores
potential future developments. It encompasses all areas of dermal
toxicity, including skin irritation, skin corrosion, skin
sensitization, UV-induced effects, and skin genotoxicity. An
individual chapter is devoted to each test method, with coverage of
the scientific basis, validation status and regulatory acceptance,
applications and limitations, available protocols, and potential
role within testing strategies. In addition, perspectives from the
test developer are presented, for example regarding critical steps
in the protocol. The closing section addresses areas that may be of
relevance for the future of dermal toxicity safety testing,
including the validation and regulatory acceptance of integrated
testing strategies, novel complex skin models, and high-throughput
screening techniques.
