Antisense Therapeutics (methods In Molecular Medicine)
by Sudhir Agrawal /
1996 / English / PDF
22.2 MB Download
Leading researchers offer an authoritative survey and analysis of
the latest findings on the rapid development of antisense
oligonucleotides therapeutic and their application in various in
vivo model systems. The book's high-profile contributors provide
timely accounts of their state-of-the-art strategies, discussing
such topics as the synthesis and purification of oligonucleotides,
their selection for a particular gene target, different methods of
administration, and the use of various cell lines and cell culture
systems. They also examine questions of cellular uptake, in vitro
biological activity, in vivo biological activity, the pharmacology
and pharmacokinetics of oligonucleotides, and the application of
oligonucleotides to the central nervous system.
Leading researchers offer an authoritative survey and analysis of
the latest findings on the rapid development of antisense
oligonucleotides therapeutic and their application in various in
vivo model systems. The book's high-profile contributors provide
timely accounts of their state-of-the-art strategies, discussing
such topics as the synthesis and purification of oligonucleotides,
their selection for a particular gene target, different methods of
administration, and the use of various cell lines and cell culture
systems. They also examine questions of cellular uptake, in vitro
biological activity, in vivo biological activity, the pharmacology
and pharmacokinetics of oligonucleotides, and the application of
oligonucleotides to the central nervous system.
