Cell And Tissue Reaction Engineering (principles And Practice)
by Ralf Pörtner /
2008 / English / PDF
5.6 MB Download
The completion of the Human Genome Project and the rapid progress
in cell bi- ogy and biochemical engineering, are major forces
driving the steady increase of approved biotech products,
especially biopharmaceuticals, in the market. Today mammalian cell
products (“products from cells”), primarily monoclonals, cytokines,
recombinant glycoproteins, and, increasingly, vaccines, dominate
the biopharmaceutical industry. Moreover, a small number of
products consisting of in vitro cultivated cells (“cells as
product”) for regenerative medicine have also been introduced in
the market. Their efficient production requires comprehensive
knowledge of biological as well as biochemical mammalian cell
culture fundamentals (e.g., cell characteristics and metabolism,
cell line establishment, culture medium optimization) and related
engineering principles (e.g., bioreactor design, process scale-up
and optimization). In addition, new developments focusing on cell
line development, animal-free c- ture media, disposables and the
implications of changing processes (multi-purpo- facilities) have
to be taken into account. While a number of excellent books
treating the basic methods and applications of mammalian cell
culture technology have been published, only little attention has
been afforded to their engineering aspects. The aim of this book is
to make a contribution to closing this gap; it particularly focuses
on the interactions between biological and biochemical and
engineering principles in processes derived from cell cultures. It
is not intended to give a c- prehensive overview of the literature.
This has been done extensively elsewhere.
The completion of the Human Genome Project and the rapid progress
in cell bi- ogy and biochemical engineering, are major forces
driving the steady increase of approved biotech products,
especially biopharmaceuticals, in the market. Today mammalian cell
products (“products from cells”), primarily monoclonals, cytokines,
recombinant glycoproteins, and, increasingly, vaccines, dominate
the biopharmaceutical industry. Moreover, a small number of
products consisting of in vitro cultivated cells (“cells as
product”) for regenerative medicine have also been introduced in
the market. Their efficient production requires comprehensive
knowledge of biological as well as biochemical mammalian cell
culture fundamentals (e.g., cell characteristics and metabolism,
cell line establishment, culture medium optimization) and related
engineering principles (e.g., bioreactor design, process scale-up
and optimization). In addition, new developments focusing on cell
line development, animal-free c- ture media, disposables and the
implications of changing processes (multi-purpo- facilities) have
to be taken into account. While a number of excellent books
treating the basic methods and applications of mammalian cell
culture technology have been published, only little attention has
been afforded to their engineering aspects. The aim of this book is
to make a contribution to closing this gap; it particularly focuses
on the interactions between biological and biochemical and
engineering principles in processes derived from cell cultures. It
is not intended to give a c- prehensive overview of the literature.
This has been done extensively elsewhere.
