Chemical Biology Of Nucleic Acids: Fundamentals And Clinical Applications (rna Technologies)
by Volker A. Erdmann /
2014 / English / PDF
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This volume contains 29 engrossing chapters contributed by
worldwide, leading research groups in the field of chemical
biology. Topics include pre-biology; the establishment of the
genetic code; isomerization of RNA; damage of nucleobases in RNA;
the dynamic structure of nucleic acids and their analogs in DNA
replication, extra- and intra-cellular transport; molecular
crowding by the use of ionic liquids; new technologies enabling
the modification of gene expression via editing of therapeutic
genes; the use of riboswitches; the modification of mRNA cap
regions; new approaches to detect appropriately modified RNAs
with EPR spectroscopy and the use of parallel and high-throughput
techniques for the analysis of the structure and new functions of
nucleic acids. This volume discusses how chemistry can add new
frontiers to the field of nucleic acids in molecular medicine,
biotechnology and nanotechnology and is not only an invaluable
source of information to chemists, biochemists and life
scientists but will also stimulate future research.
This volume contains 29 engrossing chapters contributed by
worldwide, leading research groups in the field of chemical
biology. Topics include pre-biology; the establishment of the
genetic code; isomerization of RNA; damage of nucleobases in RNA;
the dynamic structure of nucleic acids and their analogs in DNA
replication, extra- and intra-cellular transport; molecular
crowding by the use of ionic liquids; new technologies enabling
the modification of gene expression via editing of therapeutic
genes; the use of riboswitches; the modification of mRNA cap
regions; new approaches to detect appropriately modified RNAs
with EPR spectroscopy and the use of parallel and high-throughput
techniques for the analysis of the structure and new functions of
nucleic acids. This volume discusses how chemistry can add new
frontiers to the field of nucleic acids in molecular medicine,
biotechnology and nanotechnology and is not only an invaluable
source of information to chemists, biochemists and life
scientists but will also stimulate future research.