Chromatography And Modification Of Nucleosides, Part C: Modification Nucleosides In Cancer And Normal Metabolism : Methods And Applications (journal Of Chromatography Library)
by Charles W. Gehrke /
1990 / English / PDF
7.6 MB Download
Chromatography and Modification of Nucleosides is a four-volume
work which provides state-of-the-art chromatography and analytical
methods for use in a wide spectrum of nucleic acid modification
research. The focus of Part A, is the presentation of advanced
methods for modification research on tRNAs, mRNAs, mtRNAs, rRNAs
and DNAs. HPLC-UV, GC-MS, NMR, FT-IR and affinity chromatography
approaches to nucleic acid modification studies are presented, as
are nucleoside, oligonucleotide and nucleic acid isolation
techniques. Part B has as its central theme the modified
nucleosides of tRNA and the current analytical means for studying
tRNA modifications. Modified nucleoside synthesis, function,
structural conformation, biological regulation, and occurrence of
modification in a wide range of tRNAs are presented, as is a
chapter on DNA modification and a chapter on solid phase
immunoassay for determining a particular modification. Part C
provides the reader with a comprehensive treatment of modified
nucleosides as biochemical signals of neoplasia and normal
metabolism. The final volume, Part D, will present structural
characterization of unknown nucleosides as well as extensive
biochemical, chemical and physical properties of RNA and DNA
nucleosides, as a "database" for researchers in the field.
Chromatographic methodology will be described for analysis of total
modification of tRNAs and DNAs. The chapters are written by leading
scientists in their respective fields and present an up-to-date
review on the roles of modified nucleosides in nucleic acids which
will be extremely useful for workers in chromatography, molecular
biology, genetics, biochemistry, biotechnology and the
pharmaceutical industry.
Chromatography and Modification of Nucleosides is a four-volume
work which provides state-of-the-art chromatography and analytical
methods for use in a wide spectrum of nucleic acid modification
research. The focus of Part A, is the presentation of advanced
methods for modification research on tRNAs, mRNAs, mtRNAs, rRNAs
and DNAs. HPLC-UV, GC-MS, NMR, FT-IR and affinity chromatography
approaches to nucleic acid modification studies are presented, as
are nucleoside, oligonucleotide and nucleic acid isolation
techniques. Part B has as its central theme the modified
nucleosides of tRNA and the current analytical means for studying
tRNA modifications. Modified nucleoside synthesis, function,
structural conformation, biological regulation, and occurrence of
modification in a wide range of tRNAs are presented, as is a
chapter on DNA modification and a chapter on solid phase
immunoassay for determining a particular modification. Part C
provides the reader with a comprehensive treatment of modified
nucleosides as biochemical signals of neoplasia and normal
metabolism. The final volume, Part D, will present structural
characterization of unknown nucleosides as well as extensive
biochemical, chemical and physical properties of RNA and DNA
nucleosides, as a "database" for researchers in the field.
Chromatographic methodology will be described for analysis of total
modification of tRNAs and DNAs. The chapters are written by leading
scientists in their respective fields and present an up-to-date
review on the roles of modified nucleosides in nucleic acids which
will be extremely useful for workers in chromatography, molecular
biology, genetics, biochemistry, biotechnology and the
pharmaceutical industry.
