Comparative Genomics: Basic And Applied Research
by James R. Brown /
2007 / English / PDF
8.4 MB Download
When genomic research first came on the scene, much of the
biomedical research community viewed it as a limited venture with
limited potential. We now know that such an assessment was both
highly premature and wonderfully inaccurate. In the last ten years,
we’ve witnessed such remarkable acceleration in the merger of basic
and applied genomic research that, among other things, genomic
research is now thought of as being intrinsic to current drug
research. Through rigorous comparative analysis, the genomes of
cold-blooded vertebrate, avian, and other mammalian species are
providing a deeper understanding of the human genome. Moreover,
genomic sequences, which are becoming available for several species
have proven to be highly relevant to drug research with regard to a
number of otherwise intractable conditions.
When genomic research first came on the scene, much of the
biomedical research community viewed it as a limited venture with
limited potential. We now know that such an assessment was both
highly premature and wonderfully inaccurate. In the last ten years,
we’ve witnessed such remarkable acceleration in the merger of basic
and applied genomic research that, among other things, genomic
research is now thought of as being intrinsic to current drug
research. Through rigorous comparative analysis, the genomes of
cold-blooded vertebrate, avian, and other mammalian species are
providing a deeper understanding of the human genome. Moreover,
genomic sequences, which are becoming available for several species
have proven to be highly relevant to drug research with regard to a
number of otherwise intractable conditions.
Rather than offering a comprehensive volume covering every aspect
of comparative genomics,
Rather than offering a comprehensive volume covering every aspect
of comparative genomics,Comparative Genomics: Basic and
Applied Research
Comparative Genomics: Basic and
Applied Research embodies the diverse interests of prominent
researchers in the field. Compiling first hand descriptions of
their pioneering work, the text focuses on commonalities and
synergies across the broad field of comparative genomics. Among
its many topics it covers―
embodies the diverse interests of prominent
researchers in the field. Compiling first hand descriptions of
their pioneering work, the text focuses on commonalities and
synergies across the broad field of comparative genomics. Among
its many topics it covers―
· Revolutionary
advances in DNA-sequencing technology
· Revolutionary
advances in DNA-sequencing technology
· Bold new
approaches to the organization and analysis of large phylogenetic
data sets
· Bold new
approaches to the organization and analysis of large phylogenetic
data sets
· The impact of
comparative genomics on our understanding of evolution
· The impact of
comparative genomics on our understanding of evolution
· Efforts toward
developing novel antimicrobial drugs, through the use of
bacterial pathogen genomes
· Efforts toward
developing novel antimicrobial drugs, through the use of
bacterial pathogen genomes
Ultimately, future breakthroughs in comparative genomics will
depend upon the continued interaction and interdependency of
applied and basic research. This seminal volume demonstrates both
the means and the fruits of that cooperation, and in doing so
defines and lays the groundwork for continued progress.
Ultimately, future breakthroughs in comparative genomics will
depend upon the continued interaction and interdependency of
applied and basic research. This seminal volume demonstrates both
the means and the fruits of that cooperation, and in doing so
defines and lays the groundwork for continued progress.
