Cyclic Nucleotide Phosphodiesterases In Health And Disease
by Sharron H. Francis /
2006 / English / PDF
13.5 MB Download
Since the last major compendium dedicated to cyclic nucleotide
phosphodiesterases (PDEs) was published over 15 years ago, an
enormous amount of progress has occurred in the field. There is
great need for a centralized source for key information in this
burgeoning and therapeutically important area of medical research.
Since the last major compendium dedicated to cyclic nucleotide
phosphodiesterases (PDEs) was published over 15 years ago, an
enormous amount of progress has occurred in the field. There is
great need for a centralized source for key information in this
burgeoning and therapeutically important area of medical research.Cyclic Nucleotide Phosphodiesterases in Health and Disease
Cyclic Nucleotide Phosphodiesterases in Health and Disease
provides an integrated volume covering PDE biology from genes to
organisms. It examines phosphodiesterases as pharmacological
targets as well as the development of specific PDE inhibitors as
therapeutic agents. With contributions from pioneers in the
field, individual chapters describe one of the 11 known mammalian
PDE families including the molecular characteristics, structure,
function, and traits unique to each. Characteristics of PDEs from
lower organisms are also the subject of other chapters since they
provide key insights into PDE functions and are also
pharmacological targets for treatment of a variety of diseases in
humans and domestic animals. Chapters on the current biomedical
and therapeutic research on PDEs include studies on gene-targeted
knockout strategies and compartmentation in cyclic nucleotide
signaling. By unraveling the unique cellular roles for different
PDEs, scientists are beginning to open the door to the
therapeutic use of PDE inhibitors for the treatment of a number
of pathological conditions including asthma and inflammation,
pulmonary hypertension, erectile dysfunction, and stroke.
provides an integrated volume covering PDE biology from genes to
organisms. It examines phosphodiesterases as pharmacological
targets as well as the development of specific PDE inhibitors as
therapeutic agents. With contributions from pioneers in the
field, individual chapters describe one of the 11 known mammalian
PDE families including the molecular characteristics, structure,
function, and traits unique to each. Characteristics of PDEs from
lower organisms are also the subject of other chapters since they
provide key insights into PDE functions and are also
pharmacological targets for treatment of a variety of diseases in
humans and domestic animals. Chapters on the current biomedical
and therapeutic research on PDEs include studies on gene-targeted
knockout strategies and compartmentation in cyclic nucleotide
signaling. By unraveling the unique cellular roles for different
PDEs, scientists are beginning to open the door to the
therapeutic use of PDE inhibitors for the treatment of a number
of pathological conditions including asthma and inflammation,
pulmonary hypertension, erectile dysfunction, and stroke.
By collating current information into a coherent and coordinated
perspective,
By collating current information into a coherent and coordinated
perspective,Cyclic Nucleotide Phosphodiesterases in Health
and Disease
Cyclic Nucleotide Phosphodiesterases in Health
and Disease provides an invaluable reference for industry and
clinical scientists and points toward future directions of
research and therapeutic advancements in developing selective
inhibitors for these various enzymes.
provides an invaluable reference for industry and
clinical scientists and points toward future directions of
research and therapeutic advancements in developing selective
inhibitors for these various enzymes.
