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This book discusses the latest advances in basic and clinical, neuroscientific and psychiatric research into depression a severe and recurrent brain disorder that can manifest in depressive mood, somatic symptoms and cognitive impairment. The underlying mechanisms and the clinical management of the condition are subjects of long-standing interest. Presenting a biologically plausible, multilevel theory, the book describes the neural, physiological, molecular and genomic mechanisms that drive depression pathogenesis, and addresses the clinical management of the disorder. Focusing on advances made over the past 20 years in terms of the neurology, neuroimaging, physiology, pathophysiology, pharmacology and internet-based measurement and management of depressive disorder, it enables postgraduate students and academic researchers to gain a comprehensive overview of the condition. It is also useful for pharmaceutical companies developing novel drugs to treat this disease.