Drug Bioavailability (methods And Principles In Medicinal Chemistry)
by Raimund Mannhold /
2008 / English / PDF
4.8 MB Download
The gold standard for industrial research now completely revised in
line with current trends in the field, with all contributions
extensively updated or rewritten.
The gold standard for industrial research now completely revised in
line with current trends in the field, with all contributions
extensively updated or rewritten.
In 21 chapters readers can benefit from the key working knowledge
of today's leading pharmaceutical companies, including Pfizer,
AstraZeneca, and Roche. Drug developers from industry and academia
present all the factors governing drug bioavailability, complete
with practical examples and real-life data.
In 21 chapters readers can benefit from the key working knowledge
of today's leading pharmaceutical companies, including Pfizer,
AstraZeneca, and Roche. Drug developers from industry and academia
present all the factors governing drug bioavailability, complete
with practical examples and real-life data.
Part I focuses on in vitro and in vivo measurements of
physicochemical properties, such as membrane permeability and
ionization. Part II discusses solubility and gastrointestinal
absorption, while the third part is devoted to metabolism and
excretory mechanisms. The much revised and expanded part IV surveys
current in silico approaches to predict drug properties needed to
estimate the bioavailability of any new drug candidate. The final
part shows how poor bioavailability may be improved by various
approaches during the development process.
Part I focuses on in vitro and in vivo measurements of
physicochemical properties, such as membrane permeability and
ionization. Part II discusses solubility and gastrointestinal
absorption, while the third part is devoted to metabolism and
excretory mechanisms. The much revised and expanded part IV surveys
current in silico approaches to predict drug properties needed to
estimate the bioavailability of any new drug candidate. The final
part shows how poor bioavailability may be improved by various
approaches during the development process.
No other publication offers the same level of treatment on this
crucial topic in modern drug development.
No other publication offers the same level of treatment on this
crucial topic in modern drug development.