Drug Discovery And Development, Drug Development (volume 2)
by Mukund S. Chorghade /
2007 / English / PDF
3.6 MB Download
From first principles to real-world applications-here is the first
comprehensive guide to drug discovery and development Modern drug
discovery and development require the collaborative efforts of
specialists in a broadarray of scientific, technical, and business
disciplines-from biochemistry to molecular biology, organic
chemistry to medicinal chemistry, pharmacology to marketing. Yet
surprisingly, until now, there were no authoritative references
offering a complete, fully integrated picture of the process. The
only comprehensive guide of its kind, this groundbreaking
two-volume resource provides an overview of the entire sequence of
operations involved in drug discovery and develop-?ment-from
initial conceptualization to commercialization to clinicians and
medical practitioners. Volume 1: Drug Discovery describes all the
steps in the discovery process, including conceptualizing a drug,
creating a library of candidates for testing, screening candidates
for in vitro and in vivo activity, conducting and analyzing the
results of clinical trials, and modifying a drug as necessary.
Volume 2: Drug Development delves into the nitty-gritty details of
optimizing the synthetic route, drug manufacturing, outsourcing,
and marketing-including drug coloring and delivery methods.
Featuring contributions from a world-class team of experts, Drug
Discovery and Development:* Features fascinating case studies,
including the discovery and development of erythromycin analogs,
Tagamet, and Ultiva (remifentanil)* Discusses the discovery of
medications for bacterial infections, Parkinson's disease,
psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer*
Includes chapters on combinatorial chemistry, molecular
biology-based drug discovery, genomics, and chemogenomics Drug
Discovery and Development is an indispensable working resource for
industrial chemists, biologists, biochemists, and executives who
work in the pharmaceutical industry.
From first principles to real-world applications-here is the first
comprehensive guide to drug discovery and development Modern drug
discovery and development require the collaborative efforts of
specialists in a broadarray of scientific, technical, and business
disciplines-from biochemistry to molecular biology, organic
chemistry to medicinal chemistry, pharmacology to marketing. Yet
surprisingly, until now, there were no authoritative references
offering a complete, fully integrated picture of the process. The
only comprehensive guide of its kind, this groundbreaking
two-volume resource provides an overview of the entire sequence of
operations involved in drug discovery and develop-?ment-from
initial conceptualization to commercialization to clinicians and
medical practitioners. Volume 1: Drug Discovery describes all the
steps in the discovery process, including conceptualizing a drug,
creating a library of candidates for testing, screening candidates
for in vitro and in vivo activity, conducting and analyzing the
results of clinical trials, and modifying a drug as necessary.
Volume 2: Drug Development delves into the nitty-gritty details of
optimizing the synthetic route, drug manufacturing, outsourcing,
and marketing-including drug coloring and delivery methods.
Featuring contributions from a world-class team of experts, Drug
Discovery and Development:* Features fascinating case studies,
including the discovery and development of erythromycin analogs,
Tagamet, and Ultiva (remifentanil)* Discusses the discovery of
medications for bacterial infections, Parkinson's disease,
psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer*
Includes chapters on combinatorial chemistry, molecular
biology-based drug discovery, genomics, and chemogenomics Drug
Discovery and Development is an indispensable working resource for
industrial chemists, biologists, biochemists, and executives who
work in the pharmaceutical industry.