Drug Metabolizing Enzymes: Cytochrome P450 And Other Enzymes In Drug Discovery And Development
by R. Scott Obach /
2003 / English / PDF
6.2 MB Download
Critical in the elimination of drugs and other xenobiotics from the
body, cytochrome P450 has strong bearing on scientific assessments
of genetic polymorphism in metabolism, possible drug-drug
interactions, and bioavailability of candidate drugs. This text
systematizes findings on P450 and similar enzymes - as well as
parallel issues shaping the pharmaceutical industry - to promote
the next generation of safer, more effective drugs.
Critical in the elimination of drugs and other xenobiotics from the
body, cytochrome P450 has strong bearing on scientific assessments
of genetic polymorphism in metabolism, possible drug-drug
interactions, and bioavailability of candidate drugs. This text
systematizes findings on P450 and similar enzymes - as well as
parallel issues shaping the pharmaceutical industry - to promote
the next generation of safer, more effective drugs.
