Genome Editing: The Next Step In Gene Therapy (advances In Experimental Medicine And Biology)
by Matthew Hirsch /
2016 / English / PDF
6.5 MB Download
This comprehensive volume explores human genetic engineering its
pre-clinical and clinical applications, current developments, and
as treatment for hereditary diseases. It presents and evaluates
the most recent advances in the understanding of mammalian host
DNA repair mechanisms, such as double-strand break induced gene
targeting and mutagenesis, the development of zinc-finger
nucleases, genome editing for neuromuscular diseases, phase
integrases, triplex forming oligonucleotides and peptide nucleic
acids, aptamer-guided gene targeting, AAV gene editing via DSB
repair, engineered nucleases and trinucleotide repeat diseases,
and creation of HIV-resistant cells. The expertly authored
chapters contextualize current developments within the history of
genome editing while also discussing the current and potential
safety concerns of this rapidly growing field.
This comprehensive volume explores human genetic engineering its
pre-clinical and clinical applications, current developments, and
as treatment for hereditary diseases. It presents and evaluates
the most recent advances in the understanding of mammalian host
DNA repair mechanisms, such as double-strand break induced gene
targeting and mutagenesis, the development of zinc-finger
nucleases, genome editing for neuromuscular diseases, phase
integrases, triplex forming oligonucleotides and peptide nucleic
acids, aptamer-guided gene targeting, AAV gene editing via DSB
repair, engineered nucleases and trinucleotide repeat diseases,
and creation of HIV-resistant cells. The expertly authored
chapters contextualize current developments within the history of
genome editing while also discussing the current and potential
safety concerns of this rapidly growing field.Genome Editing: The Next Step in Gene Therapy
Genome Editing: The Next Step in Gene Therapy, the latest
volume in the
, the latest
volume in theAmerican Society of Gene and Cell
Therapy
American Society of Gene and Cell
Therapyseries, deftly illuminates the potential of
genetic engineering technology to eradicate today’s deadliest and
most prolific diseases. It is ideal reading for clinicians and
researchers in genetics and immunology.
series, deftly illuminates the potential of
genetic engineering technology to eradicate today’s deadliest and
most prolific diseases. It is ideal reading for clinicians and
researchers in genetics and immunology.
