I Domain Integrins (advances In Experimental Medicine And Biology)
by Donald Gullberg /
2014 / English / PDF
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The integrin family is composed of 24 members and approximately
ten years ago (2003) we published a book devoted to the nine I
domain integrin subunits. In this second edition, I am pleased
that most of the original authors have been able to contribute to
the updated version.
The integrin family is composed of 24 members and approximately
ten years ago (2003) we published a book devoted to the nine I
domain integrin subunits. In this second edition, I am pleased
that most of the original authors have been able to contribute to
the updated version.
I domain containing integrins include collagen receptors and
leukocyte receptors. In 2003 the knockout mouse phenotypes for
all of the I domain integrins had not yet been published; they
are now, and are summarized and discussed in this edition.
I domain containing integrins include collagen receptors and
leukocyte receptors. In 2003 the knockout mouse phenotypes for
all of the I domain integrins had not yet been published; they
are now, and are summarized and discussed in this edition.
Interestingly, a recent 10 integrin mutation in dogs has
indicated that collagen-binding integrins in the musculoskeletal
system might have much more severe phenotypes in larger
animals/humans compared to the mild integrin phenotypes observed
in collagen-binding integrin deficient mice. This finding is
further discussed in the book.
Interestingly, a recent 10 integrin mutation in dogs has
indicated that collagen-binding integrins in the musculoskeletal
system might have much more severe phenotypes in larger
animals/humans compared to the mild integrin phenotypes observed
in collagen-binding integrin deficient mice. This finding is
further discussed in the book.
In the cancer field, the microenvironment is taking center stage,
and here collagen receptors on fibroblasts are predicted to play
important roles in paracrine signaling, in regulating tissue
stiffness and matrix remodeling.
In the cancer field, the microenvironment is taking center stage,
and here collagen receptors on fibroblasts are predicted to play
important roles in paracrine signaling, in regulating tissue
stiffness and matrix remodeling.
New technologies, new mouse models in combination with analyses
of I integrins in larger animals/humans are thus predicted to
increase our knowledge about this group of receptors. With this
in mind we look forward to another 10 years of research with I
domain integrins.
New technologies, new mouse models in combination with analyses
of I integrins in larger animals/humans are thus predicted to
increase our knowledge about this group of receptors. With this
in mind we look forward to another 10 years of research with I
domain integrins.