Identification And Characterization Of Neural Progenitor Cells In The Adult Mammalian Brain (advances In Anatomy, Embryology And Cell Biology)
by Arturo Alvarez-Buylla /
2009 / English / PDF
3.5 MB Download
Adult neurogenesis has been questioned for many years. In the
early 1900s, a dogma was established that denied new neuron
formation in the adult brain. In the last century however, new
discoveries have demonstrated the real existence of proliferation
in the adult brain, and in the last decade, these studies led to
the identification of neural stem cells in mammals. Adult neural
stem cells are undifferentiated cells that are present in the
adult brain and are capable of dividing and differentiating into
glia and new neurons. Newly formed neurons terminally
differentiate into mature neurons in the olfactory bulb and the
dentate gyrus of the hippocampus. Since then, a number of new
research lines have emerged whose common objective is the
phenotypical and molecular characterization of brain stem cells.
As a result, new therapies are successfully being applied to
animal models for certain neurodegenerative diseases or stroke.
At present, and in years to come, this finding extends to the
adult human brain, and gives reason and hope to all the previous
studies.
Adult neurogenesis has been questioned for many years. In the
early 1900s, a dogma was established that denied new neuron
formation in the adult brain. In the last century however, new
discoveries have demonstrated the real existence of proliferation
in the adult brain, and in the last decade, these studies led to
the identification of neural stem cells in mammals. Adult neural
stem cells are undifferentiated cells that are present in the
adult brain and are capable of dividing and differentiating into
glia and new neurons. Newly formed neurons terminally
differentiate into mature neurons in the olfactory bulb and the
dentate gyrus of the hippocampus. Since then, a number of new
research lines have emerged whose common objective is the
phenotypical and molecular characterization of brain stem cells.
As a result, new therapies are successfully being applied to
animal models for certain neurodegenerative diseases or stroke.
At present, and in years to come, this finding extends to the
adult human brain, and gives reason and hope to all the previous
studies.
