Immunotherapy For Pediatric Malignancies
by Juliet C. Gray /
2017 / English / PDF
8.4 MB Download
This book provides a comprehensive overview of current
immunotherapy strategies, and how these may be applicable to
childhood cancers. The first part of the book reviews how the
immune system recognizes cancer, and the various escape
mechanisms allowing tumour growth. The importance of the tumor
microenvironment and the challenges this may present to achieving
effective immunotherapy are discussed. Monoclonal antibodies,
cellular, cytokine and vaccine therapies are all comprehensively
reviewed, with particular focus on their potential application to
pediatric cancers. Practical aspects of delivering such therapies
to children, likely toxicities and potential biomarkers are
considered. Finally, consideration is given to how, in the longer
term, such therapies may be combined with conventional therapies
such as chemotherapy and radiotherapy.
This book provides a comprehensive overview of current
immunotherapy strategies, and how these may be applicable to
childhood cancers. The first part of the book reviews how the
immune system recognizes cancer, and the various escape
mechanisms allowing tumour growth. The importance of the tumor
microenvironment and the challenges this may present to achieving
effective immunotherapy are discussed. Monoclonal antibodies,
cellular, cytokine and vaccine therapies are all comprehensively
reviewed, with particular focus on their potential application to
pediatric cancers. Practical aspects of delivering such therapies
to children, likely toxicities and potential biomarkers are
considered. Finally, consideration is given to how, in the longer
term, such therapies may be combined with conventional therapies
such as chemotherapy and radiotherapy.
Edited by two distinguished pediatric oncologists with a
collection of chapters from the most authoritative experts in
cancer immunotherapy, this is an indispensable volume for
pediatric oncologists and physicians working in childhood cancer
care.
Edited by two distinguished pediatric oncologists with a
collection of chapters from the most authoritative experts in
cancer immunotherapy, this is an indispensable volume for
pediatric oncologists and physicians working in childhood cancer
care.
