Inflammasome Signaling And Bacterial Infections (current Topics In Microbiology And Immunology)
by Steffen Backert /
2016 / English / PDF
5.3 MB Download
This volume details our current understanding of the architecture
and signaling capabilities of known canonical and non-canonical
inflammasome complexes and highlights their action, in particular
in response to infection with important bacterial model organisms
and the corresponding disease pathologies. The first chapters
review new insights into the assembly and structures of
inflammasome components and emphasize general strategies of up-
and downstream signaling events. In addition, the authors
specifically discuss the composition and activity of
inflammasomes during infection with various gut pathogens
(
This volume details our current understanding of the architecture
and signaling capabilities of known canonical and non-canonical
inflammasome complexes and highlights their action, in particular
in response to infection with important bacterial model organisms
and the corresponding disease pathologies. The first chapters
review new insights into the assembly and structures of
inflammasome components and emphasize general strategies of up-
and downstream signaling events. In addition, the authors
specifically discuss the composition and activity of
inflammasomes during infection with various gut pathogens
(Salmonella
Salmonella,
,Shigella
Shigella,
,Yersinia
Yersinia,
,Listeria
Listeria and
andHelicobacter
Helicobacter), respiratory pathogens
(
), respiratory pathogens
(Mycobacterium
Mycobacterium,
,Legionella
Legionella,
,Burkholderia
Burkholderia and
andStreptococcus
Streptococcus) as well as skin and soft tissue pathogens
(
) as well as skin and soft tissue pathogens
(Francisella
Francisella and
andStaphylococcus
Staphylococcus). The discoveries
presented provide a better understanding of the cellular and
molecular biology of inflammasomes, which will pinpoint important
new therapeutic targets for the treatment and prevention of
multiple infectious diseases in the future. It is a valuable
resource for students, scientists and clinicians, providing
up-to-date information on this emerging research topic.
). The discoveries
presented provide a better understanding of the cellular and
molecular biology of inflammasomes, which will pinpoint important
new therapeutic targets for the treatment and prevention of
multiple infectious diseases in the future. It is a valuable
resource for students, scientists and clinicians, providing
up-to-date information on this emerging research topic.
