Mechanism Of Functional Expression Of The Molecular Machines (springerbriefs In Molecular Science)
by Masahiro Kinoshita /
2016 / English / PDF
2.5 MB Download
This brief discusses the mechanism of functional expression of a
protein or protein complex utilizing the ATP hydrolysis cycle or
proton-motive force from a unique point of view focused on the
roles of water. A variety of processes are considered such as the
unidirectional movement of a linear-motor protein along a filament,
insertion of an unfolded protein into a chaperonin and release of
the folded protein from it, transport of diverse substrates across
the membrane by a transporter, and directed rotation of the central
subunit within a rotatory motor protein complex. These topics are
discussed in a unified manner within the same theoretical
framework. The author argues that water plays imperative roles in
the functional expression of these molecular machines. A pivotal
factor is the entropic force or potential originating from the
translational displacement of water molecules coexisting with the
molecular machines in the entire system.
This brief discusses the mechanism of functional expression of a
protein or protein complex utilizing the ATP hydrolysis cycle or
proton-motive force from a unique point of view focused on the
roles of water. A variety of processes are considered such as the
unidirectional movement of a linear-motor protein along a filament,
insertion of an unfolded protein into a chaperonin and release of
the folded protein from it, transport of diverse substrates across
the membrane by a transporter, and directed rotation of the central
subunit within a rotatory motor protein complex. These topics are
discussed in a unified manner within the same theoretical
framework. The author argues that water plays imperative roles in
the functional expression of these molecular machines. A pivotal
factor is the entropic force or potential originating from the
translational displacement of water molecules coexisting with the
molecular machines in the entire system.
