Medullary Thyroid Carcinoma: Biology - Management - Treatment (recent Results In Cancer Research)
by Friedhelm Raue /
2015 / English / PDF
6.2 MB Download
This book offers a comprehensive overview of medullary thyroid
carcinoma, both in the more common sporadic form and in the
familial form, multiple endocrine neoplasia (MEN) types 2A and 2B.
The coverage includes, but is not limited to, molecular biology and
genetics, pathology, clinical presentation, imaging techniques,
surgical treatment, and follow-up. The role of calcitonin as a
highly sensitive and specific tumor marker for the screening,
diagnosis, and follow-up of MTC and metastatic disease is
described, and the significance of other tumor markers is also
considered. With regard to treatment, the use of thyroidectomy is
fully discussed, including in children carrying the mutations in
the RET proto-oncogene considered causative for MEN 2.
Additionally, the value of tyrosine kinase inhibitors as the most
effective treatment modality in patients with a large tumor burden
or rapid tumor growth, or both, is explained. Medullary Thyroid
Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal
source of up-to-date information for a wide range of practitioners,
including endocrinologists, oncologists, internal medicine
specialists, geneticists, and nuclear medicine physicians.
This book offers a comprehensive overview of medullary thyroid
carcinoma, both in the more common sporadic form and in the
familial form, multiple endocrine neoplasia (MEN) types 2A and 2B.
The coverage includes, but is not limited to, molecular biology and
genetics, pathology, clinical presentation, imaging techniques,
surgical treatment, and follow-up. The role of calcitonin as a
highly sensitive and specific tumor marker for the screening,
diagnosis, and follow-up of MTC and metastatic disease is
described, and the significance of other tumor markers is also
considered. With regard to treatment, the use of thyroidectomy is
fully discussed, including in children carrying the mutations in
the RET proto-oncogene considered causative for MEN 2.
Additionally, the value of tyrosine kinase inhibitors as the most
effective treatment modality in patients with a large tumor burden
or rapid tumor growth, or both, is explained. Medullary Thyroid
Carcinoma and Multiple Endocrine Neoplasia Type 2 will be an ideal
source of up-to-date information for a wide range of practitioners,
including endocrinologists, oncologists, internal medicine
specialists, geneticists, and nuclear medicine physicians.
