Modified Nucleic Acids In Biology And Medicine (rna Technologies)
by Jan Barciszewski /
2016 / English / PDF
10.2 MB Download
This volume is comprised of 18 chapters, covering various aspects
of DNA modification and RNA modified bases. It also discusses in
detail circular RNA, therapeutic oligonucleotides and their
different properties.
This volume is comprised of 18 chapters, covering various aspects
of DNA modification and RNA modified bases. It also discusses in
detail circular RNA, therapeutic oligonucleotides and their
different properties.
The chemical nature of DNA, RNA, protein and lipids makes these
macromolecules easily modifiable, but they are also
susceptible to damage from both endogenous and exogenous agents.
Alkylation and oxidation show a potential to disrupt the cellular
redox equilibrium and cause cellular damage leading to
inflammation and even chronic disease. Furthermore, DNA damage
can drive mutagenesis and the resulting DNA sequence changes can
induce carcinogenesis and cancer progression.
The chemical nature of DNA, RNA, protein and lipids makes these
macromolecules easily modifiable, but they are also
susceptible to damage from both endogenous and exogenous agents.
Alkylation and oxidation show a potential to disrupt the cellular
redox equilibrium and cause cellular damage leading to
inflammation and even chronic disease. Furthermore, DNA damage
can drive mutagenesis and the resulting DNA sequence changes can
induce carcinogenesis and cancer progression.
Modified nucleosides can occur as a result of oxidative DNA
damage and RNA turnover, and are used as markers for various
diseases. To function properly some RNA needs to be chemically
modified post-transcriptionally. Dysregulation of the
RNA-modification pattern or of the levels of the enzymes that
catalyze these modifications alters RNA functionality and can
result in complex phenotypes, likely due to defects in protein
translation. While modifications are best characterized in
noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have
also been found to contain modified nucleosides.
Modified nucleosides can occur as a result of oxidative DNA
damage and RNA turnover, and are used as markers for various
diseases. To function properly some RNA needs to be chemically
modified post-transcriptionally. Dysregulation of the
RNA-modification pattern or of the levels of the enzymes that
catalyze these modifications alters RNA functionality and can
result in complex phenotypes, likely due to defects in protein
translation. While modifications are best characterized in
noncoding ribonucleic acids like tRNA and rRNA, coding mRNAs have
also been found to contain modified nucleosides.
This book is a valuable resource, not only for graduate students
but also researchers in the fields of molecular medicine and
molecular biology.
This book is a valuable resource, not only for graduate students
but also researchers in the fields of molecular medicine and
molecular biology.