Molecular Evolution On Rugged Landscapes: Proteins, Rna, And The Immune System
by Alan S Perelson /
1991 / English / PDF
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This book grows out of a conference held at the Santa Fe Institute March 27 to 31, 1989. The conference was organized to discuss a central emerging area of biological science: the study of adaptive processes that optimize on rugged fitness landscapes. Since Sewall Wright introduced the concept of fitness landscapes, where each genotype can be thought of as a point in a discrete genotype space and has a fitness, it has become almost second nature for biologists to conceive of adaptive evolution as “hill climbing” towards fitness peaks. Much of the basic research in population genetics, whether concerned with haploid or diploid systems, has involved analysis of the behavior of adapting populations, due to mutation, recombination, and selection, as they flow over fitness landscapes. Classical population genetics has also emphasized frequency and density-dependent selection, coevolution, the evolution of the genetic mechanisms of recombination and sex, and other issues. What then are the new strands which we sought to explore at the Santa Fe Institute meeting?
