Organic Cation Transporters: Integration Of Physiology, Pathology, And Pharmacology
by Giuliano Ciarimboli /
2015 / English / PDF
5.7 MB Download
This innovative text explores the cellular transport of organic
cations, from functional and structural properties to
pharmacological implications and psychiatric developments. The
authoritative chapters introduce organic cation transporters and
then proceed to discuss their mechanisms such as binding of
substrates and inhibitors; their drug dispositions and toxicity;
their relationships to genetic and pathophysiological
variability; and their roles in endocrine, metabolic, and
neurological systems. The final chapters delve into the use of
animal models for the study of organic cation transporter
function and their possible use in environmental cycling of
pharmaceutical residues.
This innovative text explores the cellular transport of organic
cations, from functional and structural properties to
pharmacological implications and psychiatric developments. The
authoritative chapters introduce organic cation transporters and
then proceed to discuss their mechanisms such as binding of
substrates and inhibitors; their drug dispositions and toxicity;
their relationships to genetic and pathophysiological
variability; and their roles in endocrine, metabolic, and
neurological systems. The final chapters delve into the use of
animal models for the study of organic cation transporter
function and their possible use in environmental cycling of
pharmaceutical residues.
This comprehensive volume unites integrative transporter
physiology with structural and molecular biology, genetics,
pharmacology and pathophysiology, offering a holistic approach to
utilizing this novel technique in physiological contexts. It will
prove invaluable reading for researchers and students in various
areas of integrative, organ, cell and molecular physiology as
well as pharmacologists and neurologists.
This comprehensive volume unites integrative transporter
physiology with structural and molecular biology, genetics,
pharmacology and pathophysiology, offering a holistic approach to
utilizing this novel technique in physiological contexts. It will
prove invaluable reading for researchers and students in various
areas of integrative, organ, cell and molecular physiology as
well as pharmacologists and neurologists.
