Osteosarcoma
by Takafumi Ueda /
2016 / English / PDF
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This book reviews the brilliant progress made in the past three
decades in clinical outcomes for osteosarcoma patients treated with
a multidisciplinary approach, including limb-salvage surgery
combined with neoadjuvant multidrug chemotherapy and aggressive
management of pulmonary metastasis. Osteosarcoma was a miserable
disease for adolescents and young adults until the early 1970s,
with a survival rate that was less than 10–15% even after
amputation for affected limbs because of the progression of
pulmonary metastasis. With the development of neoadjuvant
chemotherapy for osteosarcoma, including high-dose methotrexate,
doxorubicin, cisplatin, and ifosfamide during the late 1970s and
the 1980s, however, the prognosis has dramatically improved.
Limb-salvage surgery for patients with extremity osteosarcoma is
now a gold-standard surgical procedure for more than 90% of
patients with localized disease. Additionally, aggressive pulmonary
metastasectomy for patients with lung metastasis from osteosarcoma
has contributed to improvement of their survival. More recently,
carbon-ion radiotherapy has also been introduced for patients with
unresectable osteosarcoma of the trunk, as in the spine and pelvis.
In this volume the author provides valuable descriptions of an
important new treatment modality for a multidisciplinary approach
for osteosarcoma patients.
This book reviews the brilliant progress made in the past three
decades in clinical outcomes for osteosarcoma patients treated with
a multidisciplinary approach, including limb-salvage surgery
combined with neoadjuvant multidrug chemotherapy and aggressive
management of pulmonary metastasis. Osteosarcoma was a miserable
disease for adolescents and young adults until the early 1970s,
with a survival rate that was less than 10–15% even after
amputation for affected limbs because of the progression of
pulmonary metastasis. With the development of neoadjuvant
chemotherapy for osteosarcoma, including high-dose methotrexate,
doxorubicin, cisplatin, and ifosfamide during the late 1970s and
the 1980s, however, the prognosis has dramatically improved.
Limb-salvage surgery for patients with extremity osteosarcoma is
now a gold-standard surgical procedure for more than 90% of
patients with localized disease. Additionally, aggressive pulmonary
metastasectomy for patients with lung metastasis from osteosarcoma
has contributed to improvement of their survival. More recently,
carbon-ion radiotherapy has also been introduced for patients with
unresectable osteosarcoma of the trunk, as in the spine and pelvis.
In this volume the author provides valuable descriptions of an
important new treatment modality for a multidisciplinary approach
for osteosarcoma patients.
