Phenotypes And Genotypes: The Search For Influential Genes (computational Biology)
by Florian Frommlet /
2016 / English / PDF
3.8 MB Download
This timely text presents a comprehensive guide to genetic
association, a new and rapidly expanding field that aims to
elucidate how our genetic code (genotypes) influences the traits
we possess (phenotypes). The book provides a detailed review of
methods of gene mapping used in association with experimental
crosses, as well as genome-wide association studies. Emphasis is
placed on model selection procedures for analyzing data from
large-scale genome scans based on specifically designed
modifications of the Bayesian information criterion. Features:
presents a thorough introduction to the theoretical background to
studies of genetic association (both genetic and statistical);
reviews the latest advances in the field; illustrates the
properties of methods for mapping quantitative trait loci using
computer simulations and the analysis of real data; discusses
open challenges; includes an extensive statistical appendix as a
reference for those who are not totally familiar with the
fundamentals of statistics.
This timely text presents a comprehensive guide to genetic
association, a new and rapidly expanding field that aims to
elucidate how our genetic code (genotypes) influences the traits
we possess (phenotypes). The book provides a detailed review of
methods of gene mapping used in association with experimental
crosses, as well as genome-wide association studies. Emphasis is
placed on model selection procedures for analyzing data from
large-scale genome scans based on specifically designed
modifications of the Bayesian information criterion. Features:
presents a thorough introduction to the theoretical background to
studies of genetic association (both genetic and statistical);
reviews the latest advances in the field; illustrates the
properties of methods for mapping quantitative trait loci using
computer simulations and the analysis of real data; discusses
open challenges; includes an extensive statistical appendix as a
reference for those who are not totally familiar with the
fundamentals of statistics.