Protein Chromatography: Process Development And Scale-up
by Giorgio Carta /
2010 / English / PDF
5.7 MB Download
With its focus on process development and large-scale bioseparation
tasks, this is tailor-made reading for the professional bioengineer
in both the biotech and pharmaceutical industries. Following a
tried-and-tested concept, this guide has been developed over
several years in training courses for biotech and chemical
engineers in Europe and the U.S. The first part deals with the
theory, introducing chromatography and its dynamics, as well as
discussing mass transfer and dispersion effects. The second part
then goes on to cover equipment and protocols, determining the
retention factor and HETP from isocratic and elution experiments,
as well as the mass transfer and intraparticle diffusivity from
batch and shallow-bed adsorption experiments.
With its focus on process development and large-scale bioseparation
tasks, this is tailor-made reading for the professional bioengineer
in both the biotech and pharmaceutical industries. Following a
tried-and-tested concept, this guide has been developed over
several years in training courses for biotech and chemical
engineers in Europe and the U.S. The first part deals with the
theory, introducing chromatography and its dynamics, as well as
discussing mass transfer and dispersion effects. The second part
then goes on to cover equipment and protocols, determining the
retention factor and HETP from isocratic and elution experiments,
as well as the mass transfer and intraparticle diffusivity from
batch and shallow-bed adsorption experiments.
