Protein Engineering And Design
by Sheldon J. Park /
2009 / English / PDF
6.9 MB Download
Experimental protein engineering and computational protein design
are broad but complementary strategies for developing proteins
with altered or novel structural properties and biological
functions. By describing cutting-edge advances in both of these
fields,
Experimental protein engineering and computational protein design
are broad but complementary strategies for developing proteins
with altered or novel structural properties and biological
functions. By describing cutting-edge advances in both of these
fields,Protein Engineering and Design
Protein Engineering and Design aims to
cultivate a synergistic approach to protein science.
aims to
cultivate a synergistic approach to protein science.Experimental Protein Engineering
Experimental Protein Engineering
The first half of the book discusses experimental approaches to
protein engineering and starts by describing several
high-throughput screening platforms for protein engineering. Key
techniques used for diversity generation are also discussed. The
next few chapters present examples of therapeutics, enzymes,
biomaterials, and other proteins that have been engineered by
rational or combinatorial approaches. The section finishes with a
chapter on the use of non-natural amino acids in protein
engineering.
The first half of the book discusses experimental approaches to
protein engineering and starts by describing several
high-throughput screening platforms for protein engineering. Key
techniques used for diversity generation are also discussed. The
next few chapters present examples of therapeutics, enzymes,
biomaterials, and other proteins that have been engineered by
rational or combinatorial approaches. The section finishes with a
chapter on the use of non-natural amino acids in protein
engineering.Computational Protein Design
Computational Protein Design
The second half of the book introduces computational protein
design, beginning with a chapter on computational and informatics
algorithms used in protein engineering. Core components of
computational protein design are then discussed in detail, and
examples of heuristic protein design are provided. Subsequent
chapters present examples of how computational design has played
a critical role in advancing the field of protein engineering.
Concluding with a chapter outlining current challenges in the
field, this book makes computational protein design and
diversity-oriented protein engineering widely accessible to a
broad audience in academia and industry alike.
The second half of the book introduces computational protein
design, beginning with a chapter on computational and informatics
algorithms used in protein engineering. Core components of
computational protein design are then discussed in detail, and
examples of heuristic protein design are provided. Subsequent
chapters present examples of how computational design has played
a critical role in advancing the field of protein engineering.
Concluding with a chapter outlining current challenges in the
field, this book makes computational protein design and
diversity-oriented protein engineering widely accessible to a
broad audience in academia and industry alike.