Protein Structure Ed. By Eshel Faraggi
by Eshel Faraggi /
2012 / German / PDF
22 MB Download
On the topic of protein structure some of the current issues in this scientific field are discussed. The aim is that a non-expert can gain some appreciation for the intricacies involved, and in the current state of affairs. The expert meanwhile can gain a deeper understanding of the topic. Since the dawn of recorded history, and probably even before, men and women have been grasping at the mechanisms by which they themselves exist. Only relatively recently, did this grasp yield anything of substance, and only within the last several decades did the proteins play a pivotal role in this existence. Contents Preface Section 1 Introduction 1 An Evolutionary Biology Approach to Understanding Neurological Disorders 2 Structure and Dynamics of Proteins from Nuclear Magnetic Resonance Spectroscopy 3 Anhydrous and Hydrated Protein Models Derived from High-Resolution and Low-Resolution Techniques Section 2 Structure Prediction 4 Refinement of Protein Tertiary Structure by Using Spin-Spin Coupling Constants from Nuclear Magnetic Resonance Measurements 5 An Exhaustive Shape-Based Approach for Proteins' Secondary, Tertiary and Quaternary Structures Indexing, Retrieval and Docking 6 Protein Structure Alphabetic Alignment Section 3 Energy and Thermodynamics 7 Theoretical Analyses of Photoinduced Electron Transfer from Aromatic Amino Acids to the Excited Flavins in Some Flavoproteins 8 Estimating Hydrogen Bond Energy in Integral Membrane Chromoproteins by High Hydrostatic Pressure Optical Spectroscopy 9 On the Relationship Between Residue Solvent Exposure and Thermal Fluctuations in Proteins 10 Preserving Proteins Under High Pressure and Low Temperature 11 A Stable Protein - CutA1 Section 4 Function and Interaction 12 Ligand-Binding Proteins: Structure. Stability and Practical Application 13 Functional Difference Between Deuterated and Protonated Macromolecules 14 Slit/Robo Signaling: Inhibition of Directional Leukocyte Migration Section 5 Applications 15 Fibrinolytic Enzymes from Medicinal Mushrooms 16 Phospholipases A2 Protein Structure and Natural Products Interactions in Development of New Pharmaceuticals 17 Prediction and Rational Design of Antimicrobial Peptides
