Systems Analysis Of Chromatin-related Protein Complexes In Cancer
by Andrew Emili /
2013 / English / PDF
6.7 MB Download
Epigenetic modifications underlie all aspects of human
physiology, including stem cell renewal, formation of cell types
and tissues. They also underlie environmental impacts on
human health, including aging and diseases like cancer.
Consequently, cracking the epigenetic "code" is considered a key
challenge in biomedical research.
Epigenetic modifications underlie all aspects of human
physiology, including stem cell renewal, formation of cell types
and tissues. They also underlie environmental impacts on
human health, including aging and diseases like cancer.
Consequently, cracking the epigenetic "code" is considered a key
challenge in biomedical research.
Chromatin structure and function are modified by protein
complexes, causing genes to be turned “on” or “off” and
controlling other aspects of DNA function. Yet while there has
been explosive growth in the epigenetics field, human
chromatin-modifying machines have only recently started to be
characterized.
Chromatin structure and function are modified by protein
complexes, causing genes to be turned “on” or “off” and
controlling other aspects of DNA function. Yet while there has
been explosive growth in the epigenetics field, human
chromatin-modifying machines have only recently started to be
characterized.
To meet this challenge, our book explores complementary
experimental tracks, pursued by expert international research
groups, aimed at the physical and functional characterization of
the diverse repertoire of chromatin protein machines -
namely, the "readers, writers and erasers" of epigenomic marks.
These studies include the identification of RNA molecules and
drugs that interact selectively with components of the chromatin
machinery.
To meet this challenge, our book explores complementary
experimental tracks, pursued by expert international research
groups, aimed at the physical and functional characterization of
the diverse repertoire of chromatin protein machines -
namely, the "readers, writers and erasers" of epigenomic marks.
These studies include the identification of RNA molecules and
drugs that interact selectively with components of the chromatin
machinery.
What makes this book distinctive is its emphasis on the
systematic exploration of chromatin protein complexes in the
context of human development and disease networks.
What makes this book distinctive is its emphasis on the
systematic exploration of chromatin protein complexes in the
context of human development and disease networks.