The Hippo Signaling Pathway And Cancer
by Moshe Oren /
2013 / English / PDF
10.9 MB Download
The Hippo signaling pathway israpidly gaining recognition as an important player in organ sizecontrol and tumorigenesis, and many leading scientists are showingincreased interest in this growing field and it's relation to cancer.The chapters in this volumecover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few Ras, Wnt, TGFbeta and p53. Moreover, Hippo signaling is not solely involved in regulating "classic" tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. The primary audience areresearchers interested in basic science in the areas oftumor suppression, cell cycle and size regulation, development and differentiation.
