The Next Generation In Membrane Protein Structure Determination (advances In Experimental Medicine And Biology)
by Isabel Moraes /
2016 / English / PDF
6.8 MB Download
This book reviews current techniques used in membrane protein
structural biology, with a strong focus on practical issues. The
study of membrane protein structures not only provides a basic
understanding of life at the molecular level but also helps in
the rational and targeted design of new drugs with reduced side
effects. Today, about 60% of the commercially available
drugs target membrane proteins and it is estimated that nearly
30% of proteins encoded in the human genome are membrane
proteins. In recent years much effort has been put towards
innovative developments to overcome the numerous obstacles
associated with the structure determination of membrane proteins.
This book reviews current techniques used in membrane protein
structural biology, with a strong focus on practical issues. The
study of membrane protein structures not only provides a basic
understanding of life at the molecular level but also helps in
the rational and targeted design of new drugs with reduced side
effects. Today, about 60% of the commercially available
drugs target membrane proteins and it is estimated that nearly
30% of proteins encoded in the human genome are membrane
proteins. In recent years much effort has been put towards
innovative developments to overcome the numerous obstacles
associated with the structure determination of membrane proteins.This book reviews a variety of recent techniques that are
essential to any modern researcher in the field of membrane protein
structural biology. The topics that are discussed are not commonly
found in textbooks. The scope of this book includes:
This book reviews a variety of recent techniques that are
essential to any modern researcher in the field of membrane protein
structural biology. The topics that are discussed are not commonly
found in textbooks. The scope of this book includes:Expression screening using fluorescent proteins
Expression screening using fluorescent proteinsThe use of detergents in membrane protein research
The use of detergents in membrane protein researchThe use of NMR
The use of NMRSynchrotron developments in membrane protein structural
biology
Synchrotron developments in membrane protein structural
biologyVisualisation and X-ray data collection of microcrystals
Visualisation and X-ray data collection of microcrystalsX-ray diffraction data analysis from multiple crystals
X-ray diffraction data analysis from multiple crystalsSerial millisecond crystallography
Serial millisecond crystallographySerial femtosecond crystallography
Serial femtosecond crystallographyMembrane protein structures in drug discovery
Membrane protein structures in drug discovery
The information provided in this book should be of interest to
anyone working in the area of structural biology. Students will
find carefully prepared overviews of basic ideas and advanced
protein scientists will find the level of detail required to
apply the material directly to their day to day work.
The information provided in this book should be of interest to
anyone working in the area of structural biology. Students will
find carefully prepared overviews of basic ideas and advanced
protein scientists will find the level of detail required to
apply the material directly to their day to day work.
