The Oncogenomics Handbook (cancer Drug Discovery And Development)
by Richard A. Shimkets /
2005 / English / PDF
16.8 MB Download
An integrated overview of cancer drug discovery and development
from the bench to the clinic, showing with broad strokes and
representative examples the drug development process as a network
of linked components leading from the discovered target to the
ultimate therapeutic product. Following a systems biology approach,
the authors explain genomic databases and how to discover
oncological targets from them, how then to advance from the gene
and transcript to the level of protein biochemistry, how next to
move from the chemical realm to that of the living cell and,
ultimately, pursue animal modeling and clinical development.
Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec
Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva,
and Zevalin are addressed. Highlights include cancer genomics,
pharmacogenomics, transcriptomics, gene expression analysis,
proteomic and enzymatic cancer profiling technologies, and cellular
and animal approaches to cancer target validation.
An integrated overview of cancer drug discovery and development
from the bench to the clinic, showing with broad strokes and
representative examples the drug development process as a network
of linked components leading from the discovered target to the
ultimate therapeutic product. Following a systems biology approach,
the authors explain genomic databases and how to discover
oncological targets from them, how then to advance from the gene
and transcript to the level of protein biochemistry, how next to
move from the chemical realm to that of the living cell and,
ultimately, pursue animal modeling and clinical development.
Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec
Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva,
and Zevalin are addressed. Highlights include cancer genomics,
pharmacogenomics, transcriptomics, gene expression analysis,
proteomic and enzymatic cancer profiling technologies, and cellular
and animal approaches to cancer target validation.
