Topical Drug Delivery Formulations
by David W. Osborne /
2013 / English / PDF
34.5 MB Download
This book is desi-ed to provide the pharmaceutical formulator with. the fundamental understanding necessary to prepare efficacious topical drug delivery formulations, In the past the abiEty to formulate topical creams and ointments has been described as both "artFt and "ma@c." The demanding expectations of topicals include (I) formulations that have both chemical and physical stability for at least two years, (2) fornufations that have components bath, alone and in combination that are nonirritating, nonsensitizing, and nonallergenic, (3) fornutations that are at least cosmetically acceptable and preferably eosmetiealrly elsent, and (4) formulations thrat are efficacious because of their abifity to release anidlor deHver thempeutie levels of a drug. Note that these expectations are for an inherently multiple-phase system (usually an emulsion or suspension) tht contains components having a wide range af polarities and physical properties.
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