Transplant-associated Coronary Artery Vasculopathy (medical Intelligence Unit 21)
by Rohit N. Kulkarni /
2014 / English / PDF
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Cardiac transplantation has had a major impact on the quality of
life and longevity of an ever-increasing number of patients. This
benefit is significantly eroded by the development of an
accelerated form of coronary arterial disease which shows some,
but not all, of the characteristics of native coronary artery
disease, and itself is one of the major indications for
transplantation.
Cardiac transplantation has had a major impact on the quality of
life and longevity of an ever-increasing number of patients. This
benefit is significantly eroded by the development of an
accelerated form of coronary arterial disease which shows some,
but not all, of the characteristics of native coronary artery
disease, and itself is one of the major indications for
transplantation.
If cardiac transplantation is to realize its potential, it is
essential to prevent transplant-related coronary disease. This
can only be done by thorough understanding of the basic
mechanisms involved. This could help in the fight against native
atherosclerosis, which has a major impact on the community and in
preventing vascular damage after other solid organ
transplantation. To date, there is no agreement or good
guidelines about the management of chronic rejection.
Transplant-associated coronary disease is a multifactorial
disease contributed by genetic factors in the donor and
recipients. It is also linked to events occurring during brain
death, harvesting and implantation, and most importantly, events
after transplantation. The latter events can be conveniently
divided into antigen-dependent and antigen-independent with
immunological causes playing a part in both.
If cardiac transplantation is to realize its potential, it is
essential to prevent transplant-related coronary disease. This
can only be done by thorough understanding of the basic
mechanisms involved. This could help in the fight against native
atherosclerosis, which has a major impact on the community and in
preventing vascular damage after other solid organ
transplantation. To date, there is no agreement or good
guidelines about the management of chronic rejection.
Transplant-associated coronary disease is a multifactorial
disease contributed by genetic factors in the donor and
recipients. It is also linked to events occurring during brain
death, harvesting and implantation, and most importantly, events
after transplantation. The latter events can be conveniently
divided into antigen-dependent and antigen-independent with
immunological causes playing a part in both.
Recent work has resulted in major and significant accumulation of
knowledge in this field, particularly in the molecular mechanisms
and to some extent, management, of the disease. This knowledge is
extensively and methodically reviewed in this volume by a group
of experts in the field.
Recent work has resulted in major and significant accumulation of
knowledge in this field, particularly in the molecular mechanisms
and to some extent, management, of the disease. This knowledge is
extensively and methodically reviewed in this volume by a group
of experts in the field.