Validation Of Alternative Methods For Toxicity Testing (advances In Experimental Medicine And Biology)
by Chantra Eskes /
2016 / English / PDF
9.3 MB Download
This book provides information on best practices and new thinking
regarding the validation of alternative methods for toxicity
testing. It covers the validation of experimental and
computational methods and integrated approaches to testing and
assessment. Validation strategies are discussed for methods
employing the latest technologies such as tissue-on-a-chip
systems, stem cells and transcriptomics, and for methods derived
from pathway-based concepts in toxicology.
This book provides information on best practices and new thinking
regarding the validation of alternative methods for toxicity
testing. It covers the validation of experimental and
computational methods and integrated approaches to testing and
assessment. Validation strategies are discussed for methods
employing the latest technologies such as tissue-on-a-chip
systems, stem cells and transcriptomics, and for methods derived
from pathway-based concepts in toxicology.Validation of Alternative Methods for Toxicity Testing
Validation of Alternative Methods for Toxicity Testing is
divided into two sections, in the first, practical insights are
given on the state-of-the-art and on approaches that have
resulted in successfully validated and accepted alternative
methods. The second section focuses on the evolution of
validation principles and practice that are necessary to ensure
fit-for-purpose validation that has the greatest impact on
international regulatory acceptance of alternative methods. In
this context validation needs to keep pace with the considerable
scientific advancements being made in toxicology, the
availability of sophisticated tools and techniques that can be
applied in a variety of ways, and the increasing societal and
regulatory demands for better safety assessment.
is
divided into two sections, in the first, practical insights are
given on the state-of-the-art and on approaches that have
resulted in successfully validated and accepted alternative
methods. The second section focuses on the evolution of
validation principles and practice that are necessary to ensure
fit-for-purpose validation that has the greatest impact on
international regulatory acceptance of alternative methods. In
this context validation needs to keep pace with the considerable
scientific advancements being made in toxicology, the
availability of sophisticated tools and techniques that can be
applied in a variety of ways, and the increasing societal and
regulatory demands for better safety assessment.
This book will be a useful resource for scientists in the field
of toxicology, both from industry and academia, developing new
test methods, strategies or techniques, as well as Governmental
and regulatory authorities interested in understanding the
principles and practicalities of validation of alternative
methods for toxicity testing.
This book will be a useful resource for scientists in the field
of toxicology, both from industry and academia, developing new
test methods, strategies or techniques, as well as Governmental
and regulatory authorities interested in understanding the
principles and practicalities of validation of alternative
methods for toxicity testing.
