Vascular Ion Channels In Physiology And Disease
by Irena Levitan PhD /
2016 / English / PDF
15.3 MB Download
Ion channels are the major class of membrane proteins responsible
for rapid and regulated transport of ions across biological
membranes and for the generation and propagation of electrical
signals in the brain, heart, and skeletal and vascular tissues. Ion
channels are also known to play critical roles in regulation of
cell proliferation, insulin secretion and intracellular signaling
in a variety of cell types. This book focuses on the roles of
ion channels in vascular tissues under normal and pathological
conditions. Vascular abnormalities are known to underlie a
plethora of severe pathological conditions, such as
atherosclerosis, systemic and pulmonary hypertension, coronary or
cerebral vasospasm, and diabetes. In addition, misregulated
angiogenesis is one of the major contributors to the development of
tumors. Therefore, it is clearly imperative to obtain a better
understanding of the molecular mechanisms that contribute to
vascular disorders. This book will be the first comprehensive
assembly of assays to present the studies that have been done
during the last decade to elucidate the roles of ion channels in
different vascular diseases.
Ion channels are the major class of membrane proteins responsible
for rapid and regulated transport of ions across biological
membranes and for the generation and propagation of electrical
signals in the brain, heart, and skeletal and vascular tissues. Ion
channels are also known to play critical roles in regulation of
cell proliferation, insulin secretion and intracellular signaling
in a variety of cell types. This book focuses on the roles of
ion channels in vascular tissues under normal and pathological
conditions. Vascular abnormalities are known to underlie a
plethora of severe pathological conditions, such as
atherosclerosis, systemic and pulmonary hypertension, coronary or
cerebral vasospasm, and diabetes. In addition, misregulated
angiogenesis is one of the major contributors to the development of
tumors. Therefore, it is clearly imperative to obtain a better
understanding of the molecular mechanisms that contribute to
vascular disorders. This book will be the first comprehensive
assembly of assays to present the studies that have been done
during the last decade to elucidate the roles of ion channels in
different vascular diseases.
