Epigenetics And Complex Traits
by Anna K. Naumova /
2013 / English / PDF
4.5 MB Download
This book will provide an overview of basic epigenetic phenomena;
interaction between epigenetic and genetic factors; and the
influence of epigenetic factors on inheritance. Epigenetic states
may contribute to the penetrance of genetic polymorphisms or
mutations and thereby modify inheritance patterns. This may result
in non‐Mendelian inheritance of genetic traits such as observed in
common human disease. The relationship between epigenetics and
genetics, however, has not been comprehensively summarized yet. The
topic is being more and more appreciated lately due to considerable
advances in genomic and epigenomic approaches to study the origins
of human disease. The editors will focus not only on
describing epigenetic characteristics, mechanisms and results, but
also on how considerations of epigenetics can alter interpretation
and analysis of risks for complex traits. This book will be a
resource for those who have been working in human genetics or
analysis of human genetic data and are studying the impact of
epigenetics on inheritance. An overview will be given of the
impacts of inter‐individual variation in epigenetic states from
major changes (errors in genomic imprinting) that cause congenital
developmental defects to subtle changes and their impact on complex
traits. The editors will discuss the relationship between
epigenetic changes and genetic changes in human disease. Several
chapters will also focus on statistical analysis of epigenetics
effects, either in human disease genetic studies, or in population
genetics.
This book will provide an overview of basic epigenetic phenomena;
interaction between epigenetic and genetic factors; and the
influence of epigenetic factors on inheritance. Epigenetic states
may contribute to the penetrance of genetic polymorphisms or
mutations and thereby modify inheritance patterns. This may result
in non‐Mendelian inheritance of genetic traits such as observed in
common human disease. The relationship between epigenetics and
genetics, however, has not been comprehensively summarized yet. The
topic is being more and more appreciated lately due to considerable
advances in genomic and epigenomic approaches to study the origins
of human disease. The editors will focus not only on
describing epigenetic characteristics, mechanisms and results, but
also on how considerations of epigenetics can alter interpretation
and analysis of risks for complex traits. This book will be a
resource for those who have been working in human genetics or
analysis of human genetic data and are studying the impact of
epigenetics on inheritance. An overview will be given of the
impacts of inter‐individual variation in epigenetic states from
major changes (errors in genomic imprinting) that cause congenital
developmental defects to subtle changes and their impact on complex
traits. The editors will discuss the relationship between
epigenetic changes and genetic changes in human disease. Several
chapters will also focus on statistical analysis of epigenetics
effects, either in human disease genetic studies, or in population
genetics.
