Nanoparticulate Drug Delivery: Perspectives On The Transition From Laboratory To Market (woodhead Publishing Series In Biomedicine)
by Vandana Patravale /
2012 / English / PDF
3.5 MB Download
Nanoparticles offer distinct advantages in pharmaceutical
products by protecting the drug, targeting it to the diseased
tissue and providing release at the desired rate. Implementation
of this strategy in actual products, however, has proved
challenging. Nanoparticles must perform several specific tasks in
the body: they need to exhibit sufficient encapsulation of the
drug, possess requisite material characteristics to release the
drug at the desired rate and have a long enough circulation in
order to accumulate at the target in necessary quantities. The
challenges in designing nanoparticles have given rise to the
field of nanomedicine, which seeks to formulate nanoparticles to
meet the therapeutic objective.
Nanoparticles offer distinct advantages in pharmaceutical
products by protecting the drug, targeting it to the diseased
tissue and providing release at the desired rate. Implementation
of this strategy in actual products, however, has proved
challenging. Nanoparticles must perform several specific tasks in
the body: they need to exhibit sufficient encapsulation of the
drug, possess requisite material characteristics to release the
drug at the desired rate and have a long enough circulation in
order to accumulate at the target in necessary quantities. The
challenges in designing nanoparticles have given rise to the
field of nanomedicine, which seeks to formulate nanoparticles to
meet the therapeutic objective.
With this book, the authors provide a summary of the past
efforts, current status and future directions of nanomedicine.
They begin by explaining the design goals of nanoparticles to
improve drug solubility and targeting and discuss different types
of nanoparticles. Subsequent chapters include a thorough
examination of various routes of administration, including oral,
transdermal, pulmonary and intravenous. Latter parts cover
nanotoxicology, regulatory aspects in clinical trials and
concludes with an overview of case studies about nano-systems in
the marketplace.
With this book, the authors provide a summary of the past
efforts, current status and future directions of nanomedicine.
They begin by explaining the design goals of nanoparticles to
improve drug solubility and targeting and discuss different types
of nanoparticles. Subsequent chapters include a thorough
examination of various routes of administration, including oral,
transdermal, pulmonary and intravenous. Latter parts cover
nanotoxicology, regulatory aspects in clinical trials and
concludes with an overview of case studies about nano-systems in
the marketplace.
